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in absorption terms, GSH itself shows a poor diffusion through biological membranes, because of its polar and hydro-soluble nature: CLA lipophilicity improves the delivery in the follicle area of the GSH, optimizing its in situ above described action, that protects the bulb against free radicals (severe factor of risk of the hair involution process)

In a randomized, double-blind, placebo-controlled trial involving 100 children with severe obesity (612 years), alongside lifestyle interventions conducted for 6 months, the metformin group showed a greater reduction in BMI (difference between metformin and placebo groups 1.09 0.38 kg/m 2 , p = 0.006) and BMI z-score (difference between metformin and placebo groups 0.07 0.03, p = 0.02) [42]

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Biomedicine and Pharmacotherapy