Phase 2 NEJM titration (still common in research) Phase 2 retatrutide titration schedule Phase Initiation Weeks Weeks 1-4 Weekly Dose 1 mg Phase Early escalation Weeks Weeks 5-8 Weekly Dose 2 mg Phase Mid escalation Weeks Weeks 9-12 Weekly Dose 4 mg Phase High escalation Weeks Weeks 13-16 Weekly Dose 8 mg Phase Maximum Weeks Weeks 17+ Weekly Dose 12 mg Source: Jastreboff et al., NEJM 2023
Knura M, Garczorz W, Borek A, Drzymaa F, Rachwa K, George K, Francuz T
The following data was acquired from the electronic medical records for all the patients: demographics, anthropometrics, clinical presentation of symptomatic hypoglycemic episodes, history of cholecystectomy, laboratory data, information of MBS and also the time interval between surgery and the onset of hypoglycemia and therapy
Under these conditions, the water in the vial sublimates directly from solid to gas, leaving behind a stable, white crystalline structure ( lyophilized peptide )