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2.2 Negative Regulation of Ferroptosis by p53 In addition to its ferroptosis-promoting effects, p53 represses ferroptosis by inducing cyclin-dependent kinase inhibitor (CDKN1A, encoding p21), Parkinson disease 2 (PARK2) and iPLA2, or by inhibiting dipeptidyl peptidase-4 (DPP4) (Kang et al., 2019) (Figure 2)

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Similarly, lncRNA MEG3 mitigates chondrocyte ferroptosis through a competing endogenous RNA (ceRNA) mechanism, sponging miR-885-5p to enhance the expression of SLC7A11, thereby reducing lipid peroxidation and iron-dependent cell death induced by erastin (177)