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FIN56 is one ferroptosis inducer derived from CIL56, which is capable to induce cell death without activating caspases 3/7 ( 2 , which is able to oxidate iron and indirectly inactivate GPX4, thus inducing lipid peroxidation in an ALOX-independent manner ( Connection Although the majority of current research regarding ferroptosis has focused on malignancies and degenerative diseases, there remain a few investigations on ferroptosis in cutaneous diseases

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Genetic polymorphisms of Phase II enzymes is another noteworthy issue