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Multiple meta-analyzes have attempted to consolidate these findings: A systematic review found pooled IBS incidence rates of 12% among COVID-19 patients Cross-sectional studies report prevalence rates of 13% , whereas longitudinal studies show rates of 16% The subtypes distribution shows IBS-D (diarrhea-predominant) at 5% , IBS-C (constipation-predominant) at 2% , and IBS-M (mixed) at 1% The wide variation in reported figuresfrom as low as 0.17% to as high as 20%stems from differing diagnostic standards, with Rome IV criteria yielding substantially lower prevalence estimates than Rome III

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This approach may support prescribers managing patients with B12 deficiency or anemia who require non-injectable options

It activates AMPK signaling (the same pathway activated by exercise and caloric restriction), improves insulin sensitivity, enhances glucose uptake by muscle tissue, and supports mitochondrial biogenesis