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For example, NRF2 activation was found to protect cells against ionizing radiation toxicity and confer radioresistance [98]

By learning from the cutting-edge nanotechnology, some nanostrategies, including markedly improving the tumor-targeting efficiency of Pt drugs (e.g., OXA, CP, and prodrugs) and delivering anti-ROS agents (e.g., antioxidant drugs and inorganic NPs), have been developed to prevent and/or treat PIPN

It has a key role in cellular protection, detoxification processes and strengthening the immune system

Therapeutic approaches focus primarily on stabilizing mitochondrial membranes and enhancing mitophagy to limit mtDNA leakage