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Every element is anchored to specific numbers from the analysis

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However, long-term safety data including cardiovascular outcomes, heart-rate effects, and optimal dosing are still being gathered in Phase 3 studies, and no definitive safety conclusions can be drawn at this stage

Replacement of the GLP-2 middle region (residues 719) that mainly interacts with TM1, TM7 and ECL1 by the corresponding part of GLP-1, almost abolished GLP-2R-mediated cAMP accumulation but fully rescued that induced by GLP-1R (Fig