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In most cases, this is more relevant to pigmentation-related response and receptor sensitivity than to the neuroendocrine or sexual-arousal pathways more strongly linked to other melanocortin receptors in the brain

It is the same mechanism that makes pyridoxine effective for pregnancy nausea, chemotherapy-induced nausea, and motion sickness

Animal models often have low predictive validity for human diseases

Although, a number of experimental techniques like peptide modification are available in order to improve peptide stability with high accuracy [5, 38], yet these experimental procedures are costly and time consuming