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10.1016/s0140-6736(17)30069-7 58

By employing nanoparticles or liposomal carriers, the bioavailability, stability and targeted delivery of these compounds could be enhanced, ensuring that they reach the bladder tissue in higher concentrations while minimizing systemic side effects

To allow GLP1R to be precisely visualized and interrogated, we set out to CRISPR engineer a mouse model in which a SNAP-tag enzyme self-label is knocked into the N -terminus, between the signal peptide and ectodomain of the GLP1R

Replacement of GLP-2R ECL1 by poly-alanine abolished the ability of GLP-2 to elicit cAMP response, while replacement by that of GLP-1R diminished its potency by 196-fold