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If a patient stops taking Suboxone for more than 1-2 days, returns to opioid use, then tries to restart Suboxone, the patient will likely experience sudden and severe opioid withdrawal symptoms that mimic flu-like symptoms (muscle aches, nausea, vomiting, sweating, chills, tremors and diarrhea)

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In this study, we found by mRNA sequencing that a variety of genes involved in cell cycle regulation, DNA replication and mitosis were significantly up-regulated in RRM2 overexpressing cells ( RRM2 -OE-TPC-1) in the experimental group, as shown in the Supplementary Table 4