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While this finding is of great interest to the field of konzo as well as other neurodegenerative diseases, we cannot determine if the reduction in GPx3 is a result of disease or an inherent contributing factor for disease that is triggered by a micronutrient deficiency or underlying genetic variability

Victor P, Sarada D, Ramkumar KM (2021) Crosstalk between endoplasmic reticulum stress and oxidative stress: focus on protein disulfide isomerase and endoplasmic reticulum oxidase 1

Therefore, we established a mouse model of CaOx crystal-induced kidney injury using intraperitoneal injection of glyoxylate, in compliance with some previous studies [30,31,32]

doi: 10.1038/s41598-017-11779-9 Summary Keywords gut microbiota, hypothyroidism, immune regulation, probiotics, prebiotics, microbiota-targeted therapy Citation Jiang T, Yang X, Wu B, Tao R, Chen R, Jin L, Sun D and Weng H (2025) Gut microbiota in hypothyroidism: pathogenic mechanisms and opportunities for precision microbiome interventions