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Lower Metabolic Risk: Preferred for Metabolically Vulnerable Patients Bupropion (Wellbutrin): Unique among antidepressants for consistent weight loss or neutrality Average 2-5 pound weight loss in studies Mechanisms include dopamine/norepinephrine effects, possible appetite suppression Does NOT cause sexual dysfunction (unlike SSRIs) Activating (helps energy, can improve motivation) No significant adverse metabolic effects on glucose or lipids Limitations: Can worsen anxiety (not appropriate for patients with primary anxiety disorders) Contraindicated in seizure disorders Contraindicated in active eating disorders (anorexia, bulimia) due to seizure risk Can cause insomnia if taken too late in the day Clinical bottom line: First-line choice for depression in patients with obesity or metabolic concerns (unless specific contraindications)

Heart Rate Increase: Mean increases in resting heart rate of 2 to 3 beats per minute (bpm) were observed in patients treated with Liraglutide

However, Lilly narrowed the revenue gap considerably during the second quarter, since Wegovys DKK 11.659 billion ($1.706 billion) was just 37% ahead of Zepbounds Q2 revenuecompared with Q1, when Wegovys DKK 9.377 billion ($1.372 billion) was more than double Zepbounds revenue

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