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DEFB1 is an antimicrobial peptide which is highly expressed and active in the gut 88 , playing a potentially important role in maintaining gutmicrobiome homeostasis 89

The wild-type enzyme did not hydrolyze the substrate, and thus, the introduction of a single histidine residue transformed the wild-type enzyme into a turnover system for thiol-ester hydrolysis

While B12 supplementation addresses the deficiency, injection may be recommended by a healthcare provider as opposed to oral supplementation since malabsorption is often the cause

Think of glutathione as your internal guardian, protecting your cells from harm and ensuring your body operates at its best