Testosterone acts as a neuroactive steroid affecting brain regions involved in emotional processing including the amygdala and prefrontal cortex Correcting genuine testosterone deficiency typically improves mood, reduces depression and anxiety, and enhances emotional resilience Supraphysiological doses or fluctuating testosterone levels may trigger irritability, mood swings, or emotional instability Regular monitoring of testosterone levels and dose adjustments help minimise emotional side effects and optimise treatment outcomes Severe depression, suicidal thoughts, uncontrollable anger, or psychotic symptoms require urgent medical assessment Table of Contents How Testosterone Treatment Affects Mood and Emotions Testosterone replacement therapy (TRT) can influence emotional regulation and mood, though effects vary considerably between individuals
For these reasons, several drugs have been explored for their protective effects in oxidative stress in vitro models and ischemic stroke mouse models (middle cerebral artery occlusion/reperfusion)
The convergence of functional medicine principles with cutting-edge pharmaceutical research exemplifies the future of medicine where we address root causes using all available tools, whether natural or pharmaceutical, always keeping the individual patient at the center of care
JCI Insight 3 , e96795 (2018)
