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Most studies using DPP4 inhibitors to treat human subjects with type 2 diabetes demonstrate increased levels of intact GLP-1 and GIP, and often a reduction of total circulating GLP-1 and GIP, consistent with feedback inhibition of L and K cell secretion, respectively (174)

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You should discuss libido changes with your doctor if you experience new or worsening decreased sexual desire that persists for more than 2-4 weeks, particularly if it affects your quality of life or relationships