van Os J, Kenis G, Rutten BPF
When the peptide binds to these receptors, it initiates a signaling cascade that increases the expression of lipolytic enzymes, particularly hormone-sensitive lipase, which breaks down stored triglycerides into free fatty acids and glycerol
However, except for hydroxyl radical, -CA displays a much lower scavenging capacity for 2,2-diphenyl-1-picrylhydrazylhydrate (DPPH) superoxide anion radicals and H 2 O 2 compared to its analogs (e.g., ferulic acid)
Alternative strategies, such as matrix-mimicking systems or spheroid cell culture models using low-passage chondrocytes, which better replicate physiological conditions, could provide new insights into their response to oxidative stress, and offer advantages for studying ECM dynamics