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Tesamorelin's GHRH mechanism is tissue-specific to the pituitary

However, it is important to recognise that absence from official documentation does not mean sleep problems never occur

The review further outlines GH-independent effects of the class on sleep pattern, food intake, and cardiovascular function, and highlights the then-recent discovery of ghrelin as the endogenous GHS-receptor ligand

Due to the detrimental effects of all constituent elements of MetS on the endothelium, it is plausible that endothelial dysfunction is more prevalent among individuals with MetS