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Vitamin, mineral, and other nutrient depletion is an effect of taking these drugs that has been documented since the 1960s, leading many researchers and pharmacists to recommend supplementing with vitamins and minerals while using these medications

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The study found that while glutathione was elevated, other vital protective antioxidant enzymessuch as mitochondrial superoxide dismutase (SOD2)were severely depleted

Preliminary clinical experience with a new natural compound in the treatment of oesophagitis and gastritis: symptomatic effect