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Abbreviations GLP-1RAs Glucagon-like peptide-1 receptor agonists T2DM Type 2 diabetes mellitus DPP-4 Dipeptidyl peptidase IV GLP-1R Glucagon-like peptide-1 receptor cAMP Cyclic adenosine monophosphate PKA Protein kinase A PI3K Phosphatidylinositol 3-kinase Akt Protein kinase B AD Alzheimers diseases TRPV1 Transient receptor potential vanilloid 1 OA Osteoarthritis KOA Knee OA MIA Monoiodoacetate IL-6 Interleukin 6 PGE2 Prostaglandin E2 NO Nitric oxide ER Endoplasmic reticulum IL-1 Interleukin-1 MMP-3 Matrix metalloproteinases-3 MMP-13 Matrix metalloproteinases-13 ROS Reactive oxygen species BMI Body mass index IBS Irritable bowel syndrome ATP Adenosine triphosphate SERT Serotonin transporter TPH-1 Tryptophan hydroxylase-1 AC Adenylate cyclase LPS Lipopolysaccharide WAS Water avoidance stress IBS-C Constipation-predominant IBS SNL Spinal nerve ligation SCI Spinal cord injury CHOP C/EBP homologous transcription factor protein GRP78 Glucose regulatory protein 78 PSNT Partial sciatic nerve transection L