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Dysfunction in protein clearance by the proteasome: impact on autoinflammatory diseases

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202 Intra-articular injection of an anti-IL-17 neutralizing antibody reduced the expression of Cdkn1a , a marker of joint degeneration and aging

Upregulation of LRP-1 solely in response to -synuclein pathology may be a compensatory clearing mechanism, further supported by the neuroprotective effects of inhibition of the LRP-1-cleaving Furin