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GLP-1 agonists In the late 1980s a group of scientists identified the first GLP-1 agonist (Exendin-4) in animals

doi: 10.1038/sj.onc.1205556 215 Ramirez de MolinaASarmentero-EstradaJBelda-IniestaCTaronMRamirez de MolinaVCejasPet al

So, they arent causing damaging reactions and the cell stays healthy

Prog Neuropsychopharmacol Biol Psychiatry 91:94102 Draganov M, Vives-Gilabert Y, de Diego-Adelio J et al (2020) Glutamatergic and GABA-ergic abnormalities in First-episode depression