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The Semaglutide cohort compared to the non-GLP-1RA anti-obesity medications cohort was older, had a lower prevalence of adverse socioeconomic determinants of health, mental disorders, and substance use disorders, and a higher prevalence of morbid obesity, T2D and obesity-associated comorbidities

However, this approach lacks official recommendations and has not undergone thorough clinical testing to ensure its safety and effectiveness

These include producing short-chain fatty acids (SCFAs) such as butyrate and propionate, which can stimulate L-cell activity and enhance GLP-1 secretion

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