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Journal of Clinical Endocrinology & Metabolism, 106 (3), 650-663

The drugs makers, Novo Nordisk and Eli Lilly, excluded people who were pregnant or planned to become pregnant from their clinical trials, a common practice when testing new medicines

Although the size increased, the size of the functionalized nanoparticles was still in a range that was deemed suitable for topical application, indicating that the HA functionalization did not affect the desired delivery essentials of the nanoparticles on the skin

Ronis MJJ, Huang J, Crouch J, Mercado C, Irby D, Valentine CR, Lumpkin CL, Ingelman-sundberg M, Badger TM: Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentration in rats