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No contraindications (e.g., certain endocrine conditions, pancreatitis history, medication conflicts)

H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)

Carnitine deficiency results in an inability to utilise fatty acids as an energy source, and causes skeletal muscle dysfunction and weakness, heart enlargement, heart failure and rhythm disturbances and liver dysfunction