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It has been found that after knocking out the DPP4 gene in rats, metformin could still dose-dependently increase GLP-1 concentrations (Yasuda et al., 2002)

Effect of naltrexone-bupropion on major adverse cardiovascular events in overweight and obese patients with cardiovascular risk factors

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GLP-1 receptor agonists are MHRA-licensed prescription medicines with extensive clinical trial evidence for type 2 diabetes and obesity management