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Several clinical trials demonstrated that TLK286 was active and safe to use in combination treatment regimens with standard chemotherapeutic agents, including platinums, taxanes, and anthracyclines

Morphologically, ferroptosis is characterized by necrotic-like features, including loss of mitochondrial cristae, increased membrane density, outer membrane rupture, and reduced mitochondrial volume, while preserving plasma membrane integrity during early stages and maintaining normal nuclear morphology

Moreover, it contributed to the induction of apoptosis in about 50% of the cells [139]

Our approach enabled us to test four different hypotheses (Table 1) regarding the impact of preparation conditions on plasma GSH measures