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Most studies on gastroparesis have focused on AL and ATTRv amyloidosis, with limited case reports on AA amyloidosis
It was originally isolated as a partial sequence of a naturally occurring protein found in human gastric juice, first characterized in the early 1990s by researchers at the University of Zagreb
The main reason is receptor desensitization : continuous stimulation of the same receptor makes cells less responsive over time, so a planned off period lets the receptor resensitize
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