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According to NICE, Wegovy should only be used within specialist weight management services, generally for people with a BMI 35 kg/m (lower thresholds may apply for some minority ethnic groups) with at least one weight-related comorbidity, and for a maximum duration of 2 years

Turton MD, O'Shea D, Gunn I, Beak SA, Edwards MB, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JPH, Smith DM, Ghatei MA, Herbert J, Bloom SR

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Genomic DNA analysis identified several variants of APE1 (L104R, E126D, R237A, D283A, D148E, G306A, and G241R) that were over-represented in ALS patients compared to controls