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Three weeks later, intraperitoneal injection of clozapine-N-oxide (CNO, a ligand of the chemogenetic designer receptor) at 1 h after morphine administration, which significantly increased both the output and water content of feces in hM3Dq-expressing mice compared to mCherry-expressing control mice (Fig

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Each variant received a TP53 enrichment score wherein a negative TP53 enrichment score is representative of a variant which was depleted in the treatment population as compared to the untreated control population (Fig