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Acylcarnitines produced as products of incomplete mitochondrial fatty acid oxidation have been detected in obesity, type 2 diabetes, cardiovascular disease, encephalopathy, and diseases of the eye, while patients with peroxisomal biogenesis disorders, such as Zellweger syndrome or X-linked adrenoleukodystrophy, or with acidemias have abnormal profiles of circulating acylcarnitines

Options include staying at your current dose longer before increasing, temporarily reducing to your previous dose level, implementing more aggressive side effect management strategies, or in some cases discontinuing treatment

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In this study, we demonstrated the hepatoprotective effect of NTZ, an antiprotozoal drug, against MTX-induced hepatotoxicity