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Small-scale studies in patients on hemodialysis show promising results with decreased risk of hypoglycemia, reduction in insulin dose requirement, and improved glycemic control with use of GLP1-RA 15,16

Among them, 150 patients with covert HE evaluated using PHES underwent randomization

But searching everywhere, eventually people started looking at CRP C-reactive protein and then things started to roll in the direction of the immune system, of the inflammatory and anti-inflammatory actions of the compounds

As most discontinuations occurred during the rapid dose-escalation period of treatment, slower up-titration of dose may counter these