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The range of uses for loop diuretics is broad and includes generalized edema, pulmonary edema, hypertension, heart failure, hypercalcemia, oliguria (diminished urine output), ascites, and anion overload

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At the low pH required to keep ascorbic acid stable (typically pH 2.5 to 3.5), it donates electrons to Cu2+, reducing it to Cu1+

In support of a role of NRF2 in OSA, it has also been found that restoration of NRF2 activity can mitigate cognitive impairment and inflammation in a model of IH and sleep fragmentation by modulating ER stress and regulating the expression of the antioxidant gene Prdx1 (Qiu et al