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The analysis of secondary CV outcomes showed that nonfatal stroke was also significantly lower in the dulaglutide group compared with placebo (2.7% vs 3.5%, P = .017), however, dulaglutide did not show any effects on all-cause mortality ( P = .067)

Their effects are more likely to counteract retatrutide heart rate increases because nifedipine (an L-type calcium channel blocker) was shown to partially reduce retatrutide cardiac effects in laboratory studies

some reviews suggest modest average weight changes in certain populations, though results vary and evidence quality differs across studies

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