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Retatrutide is a synthetic multi-agonist peptide designed to activate three key metabolic pathways at once: GLP-1 receptor for appetite suppression and glucose-dependent insulin secretion GIP receptor for enhanced insulin sensitivity and lipid metabolism Glucagon receptor for increased energy expenditure and lipolysis This triple mechanism delivers more comprehensive metabolic effects than dual agonists like tirzepatide, making Retatrutide a leading tool in current incretin, obesity, and metabolic research

Mitophagy, the selective autophagic clearance of mitochondria, serves a key inhibitory role against ferroptosis (44)