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In a population-based study of 467 matched pairs of GLP-1RA users and non-users with T2D and liver cirrhosis, GLP-1RA use was associated with lower risks of death, cardiovascular events, decompensated cirrhosis, hepatic encephalopathy, and liver failure (101)
Bugg, J
5.6 Necrotizing Fasciitis of the Perineum (Fourniers Gangrene) Reports of necrotizing fasciitis of the perineum (Fourniers Gangrene), a rare but serious and life-threatening necrotizing infection requiring urgent surgical intervention, have been identified in postmarketing surveillance in patients with diabetes mellitus receiving SGLT2 inhibitors, including dapagliflozin
Furthermore, GLP-1 has been shown to stimulate calcitonin secretion from the thyroid gland, which may further contribute to protective effects on bone, 25 but whether this action is relevant in humans still needs to be clarified
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