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It was reported that the exposure to the anesthetic drug, sevoflurane, in the early development could lead to persistent impairment of learning and memory in rodents (Lee et al., 2014), and that this effect was related to the activation of RhoA signaling pathway as the sevoflurane induced shortening of the dendritic protrusion length was blocked by the treatment of the ROCK inhibitor, Y27632 (Zimering et al., 2016)

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