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As a member of the emerging class of mitochondrial-derived peptides (MDPs), MOTS-c has attracted significant research interest for its role in mitochondrial-nuclear communication, metabolic homeostasis signaling, and cellular stress response pathways in controlled laboratory settings

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K., Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2015 , 148 , 18

Because the peptide engages GIPR, GLP-1R, and GCGR within a single molecular scaffold, it is especially useful in experimental models designed to examine how receptor signaling, energy metabolism, and endocrine pathway regulation interact across tissues rather than in isolation