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In addition to increased ROS production, a study by Zhu et al

But suffice it to say the compound rapamycin was identified first long before a really amazing guy named David Sabatini as a PhD student at Hopkins in 1993, 1994 as a side project in a lab made the discovery that this thing, rapamycin, was actually working by inhibiting a protein complex of which TOR, target of rapamycin, as it became named was the central piece