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Birth Defects and Decreased IQ Inform pregnant women and women of childbearing potential (including girls beginning the onset of puberty) that use of valproate during pregnancy increases the risk of birth defects, decreased IQ, and neurodevelopmental disorders in children who were exposed in utero

Emerging multi-objective frameworks, including AB-Gen and AntBO, aim to address these challenges by concurrently optimizing for binding efficacy, stability, immunogenicity and manufacturability

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200,201 Silverman Bonnifield and colleagues provide an up-to-date overview of the lead problem and of the role of regulatory success in addressing it