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The scope of the review is intentionally selective rather than exhaustive, focusing on peptidereceptor systems that demonstrate biological plausibility, mechanistic coherence, and unmet therapeutic potential, yet lack approved therapeutic analogs or advanced clinical programs

This persistent elevation of unbound bilirubin may pose a risk, particularly in neonates and pregnant individuals [160]

It invites readers to see medicine not merely as a science of intervention, but as a discipline of perception, empathy, and awarenessan approach essential for thoughtful practice in the 21st century

In conclusion, GLP-1 receptor agonists show potential in heart failure management through their multiple mechanisms of action, including direct cardioprotective effects, vasodilation, natriuresis, and glucose and weight control