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Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells

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Specifically, carriers of GIPR variants that are pharmacologically classified as loss-of-function variants with reduced cell surface expression, cAMP production, beta arrestin 2 recruitment, internalization, and endosomal signaling have consistently been associated with lower adiposity-related traits, including BMI (103) and nominally lower prevalence of obesity (39, 9799)

Diabetes is a condition that prevents the body from effectively turning food into energy