glp-1 and berberine Frontiers Is Using Berberine for Weight

NYHA=New York Heart Association

There's limited evidence that doses above 600mcg provide additional benefit

Absolute contraindications include: Personal or family history of medullary thyroid carcinoma : These medications carry a boxed warning regarding thyroid C-cell tumors based on rodent studies Multiple endocrine neoplasia syndrome type 2 (MEN 2) : Increased risk of medullary thyroid carcinoma Previous serious hypersensitivity reaction : To semaglutide, tirzepatide, or any formulation component Pregnancy considerations: These medications are not recommended during weight management in pregnancy due to limited safety data and potential fetal risks

Wegovy if prescribed for cardiovascular risk reduction in adults with obesity/overweight + established heart disease