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That gap between them reflects something clinically important

Food and Drug Administration , 2025

And if youre losing fluid through vomiting or diarrhea side effects, dehydration can happen and, in some cases, can even become severe enough to cause kidney problems

Previous GLP-1 agonist cardiovascular trials were conducted primarily in diabetic populations, leaving open the question of whether the heart benefits were mediated through glucose management or through direct cardiovascular effects of GLP-1 receptor activation