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Front Nutr 10:1142784

You would not know the concentration has dropped until you notice reduced effectiveness

Although the CR group exhibited significantly lower lumbar spine and hip BMD compared to controls, there were no significant differences in serum CTX, bone-specific alkaline phosphatase (BSAP) levels, or trabecular microarchitecture parameters (e.g., erosion index, surface-to-volume ratio) between the groups