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Letrozole has a longer half-life (approximately 4 days) and reaches steady-state plasma concentrations over a longer period (60 days) ( Recent clinical publications have highlighted the dermatologic toxicities induced by aromatase inhibitors (AIs) ( Alopecia is particularly common in BC patients treated with AIs, with a notable incidence among AEs ( Our analysis found positive signals for onychoclasis, vascular responses (e.g., hypersensitivity vasculitis, vascular purpura), hair abnormalities (e.g., alopecia, androgenetic alopecia, hair growth abnormality), and nail toxicity (e.g., nail disorder, discoloration, nail dystrophy) across all three AIs, indicating a need for appropriate patient care

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and (c) overweight/obese (Ow/Ob): 8 individuals without history of gastrointestinal surgery (control group)

The combined estimated incidence rate of any new retinopathy in these participants was 70.2 (95% CI 62.8, 78.3) per 1000 person-years