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Chronic nasal insulin/L-penetratin treatment retarded the progression of mild cognitive dysfunction and memory loss in SAMP8 mice at 1624 weeks of age, an early stage of memory loss (Kamei et al., 2017)

Adverse Reactions/Side Effects Mild transient diarrhea, itching, transitory exanthema, feeling of swelling of entire body, and anaphylaxis

Endocrine physiology

Thus, both exercise and tDCS can be viewed as tools for inducing specific optimal brain states (neural priming): exercise acts as a global activator regulating overall brain excitability, while tDCS enables precise targeting of specific brain regions for therapeutic intervention