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Jumping to the maintenance dose immediately leads to significant gastrointestinal side effects that can derail an entire protocol

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Doses above 2ml per injection may elevate homocysteine levels if B-vitamin cofactors (B6, B12, folate) are insufficient, which can contribute to vascular inflammation over time

Treatment options include surgical resection, chemotherapy (often using drugs like doxorubicin and ifosfamide), radiation therapy, and newer targeted therapies, such as MEK inhibitors, which focus on specific genetic mutations in the tumor