In the neonatal period, or the first 28 days of life, infants will show: low muscle tone, or hypotonia, with poor suck Between 1 month and 2 years of age, babies will show: hypotonia with poor suck and appetite in the neonatal period developmental delay Between ages 2 and 6, children will show: hypotonia with a history of poor suck developmental delay Between 6 and 12 years of age: history of hypotonia with poor suck developmental delay excessive eating with abdominal obesity if uncontrolled externally From age 13 years into adulthood, individuals will show: cognitive problems, usually mild intellectual disability excessive eating and uncontrolled hunger (hyperphagia), with abdominal obesity if uncontrolled externally hypogonadism, or little to no hormone production by the testicles or ovaries, and/or typical behavioral findings Genetic testing After clinical criteria are met, genetic tests will be done to look for abnormalities that affect a specific section, called the PWS locus, of the paternal chromosome 15 the underlying PWS cause
By mitigating oxidative damage in animals exposed to captivity stress or environmental toxins, antioxidants have been used to improve breeding success rates, exemplified by their use in endangered amphibian programs
All double interactions and triple interaction were also not significant
The guidance for neurological symptoms, recommending every-other-day injections, further highlights that the standard maintenance dose is not universally sufficient
