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IGF-1 derivatives have played important roles in research studies on cell proliferation, cell division, and cell-to-cell communication

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To more definitively identify complexes containing both ASPL and VCP, we immunoprecipitated endogenous ASPL from the 3-FLAGASPL cells using anti-FLAG antibody

The addition of exogenous ROS results in resensitization of cells with high VRK2 expression to GSH inhibition, which is consistent with the fact that PC cells with low expression of VRK2 are susceptible to GSH inhibition attributes to its high basal ROS level, suggesting that cells in a state of oxidative stress have enhanced dependence on the GSH system