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*Correspondence: Lili Zhou, [email protected] These authors have contributed equally to this work This article was submitted to Renal Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Endogenous creatine synthesis also consumes methyl groups, so high creatine demand may place additional pressure on SAM-dependent methylation

& Wang, C.-Y

L-Glutathione reduced is capable of scavenging oxygen-derived free radicals and is established to be a marker of oxidative stress [1]